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E3 ligase Ligand-Linker Conjugates 4

" in MedChemExpress (MCE) Product Catalog:

6

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Click Chemistry

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-103601
    (S,R,S)-AHPC-PEG4-N3

    VH032-PEG4-N3; VHL Ligand-Linker Conjugates 5; E3 ligase Ligand-Linker Conjugates 4

    		 E3 Ligase Ligand-Linker Conjugates Others
    (S,R,S)-AHPC-PEG4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
    (S,R,S)-AHPC-PEG4-N3
  • HY-103615
    Thalidomide-O-amido-C4-N3
    1 Publications Verification

    Cereblon Ligand-Linker Conjugates 4; E3 ligase Ligand-Linker Conjugates 18

    		 E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis Others
    Thalidomide-O-amido-C4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-amido-C4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
    Thalidomide-O-amido-C4-N3
  • HY-103604
    (S,R,S)-AHPC-PEG4-NH2 hydrochloride
    2 Publications Verification

    VH032-PEG4-NH2 hydrochloride; VHL Ligand-Linker Conjugates 4 hydrochloride; E3 ligase Ligand-Linker Conjugates 7

    		 E3 Ligase Ligand-Linker Conjugates Cancer
    (S,R,S)-AHPC-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.
    (S,R,S)-AHPC-PEG4-NH2 hydrochloride
  • HY-103604A
    (S,R,S)-AHPC-PEG4-NH2
    2 Publications Verification

    VH032-PEG4-NH2; VHL Ligand-Linker Conjugates 4 ; E3 ligase Ligand-Linker Conjugates 7 Free Base

    		 E3 Ligase Ligand-Linker Conjugates Cancer
    (S,R,S)-AHPC-PEG4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.
    (S,R,S)-AHPC-PEG4-NH2
  • HY-128821
    cIAP1 Ligand-Linker Conjugates 4

    E3 ligase Ligand-Linker Conjugates 42

    		 E3 Ligase Ligand-Linker Conjugates Cancer
    cIAP1 Ligand-Linker Conjugates 4 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 4 can be used to design SNIPERs .
    cIAP1 Ligand-Linker Conjugates 4
  • HY-130822
    K-Ras ligand-Linker Conjugate 4

    		Target Protein Ligand-Linker Conjugates Cancer
    K-Ras ligand-Linker Conjugate 4 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 4 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells .
    K-Ras ligand-Linker Conjugate 4

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